Effect of raloxifene on IGF-I and IGFBP-3 in postmenopausal women with breast cancer. |
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| Authors: | R Torrisi L Baglietto H Johansson G Veronesi B Bonanni A Guerrieri-Gonzaga B Ballardini A Decensi |
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| Affiliation: | Division of Chemoprevention, European Institute of Oncology, via Ripamonti 435, 20141 Milan, Italy. |
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| Abstract: | The effect on the IGF system of 60 mg and 600 mg daily of raloxifene administered for 2 weeks prior to surgery was investigated in 37 postmenopausal women with breast cancer. Raloxifene significantly decreased insulin-like growth factor (IGF-I) as compared to placebo (P < 0.05) with no dose-response relationship. No significant change was observed in IGFBP-3, while the IGF-I/IGFBP-3 molar ratio was decreased by treatment, with a statistically significant effect only for the higher dose. Given that high plasma levels of IGF-I have been suggested as a risk factor for breast cancer, these findings provide further support for the potential activity of raloxifene in breast cancer prevention. |
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| Keywords: | breast cancer prevention SERMs IGF system |
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