| 1-乙酰-4-(4-羟基苯基)哌嗪合成的改进 |
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| 引用本文： | 林寒芬,岳翔,陈文彬. 1-乙酰-4-(4-羟基苯基)哌嗪合成的改进[J]. 中国医药工业杂志, 1988, 0(2) |
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| 作者姓名： | 林寒芬 岳翔 陈文彬 |
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| 作者单位： | 上海医药工业研究院，上海医药工业研究院，上海医药工业研究院 |
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| 摘 要： | 二乙醇胺经溴化、环合一锅合成 N-(4-甲氧苯基)哌嗪氢溴酸盐(3),解决了劳动保护问题。酰化收率经改进从26%提高至70%以上,总收率26.4%,适合工业生产。
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| 关 键 词： | 酮康唑 1-乙酰-4-(4-羟基苯基)哌嗪 合成 |
IMPROVED PREPARATION OF 1-ACETYL 4-(4-HYDROXYPHENYL)PIPERAZINE |
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| LIN Han-Fen YUE Xiang CHEN Wen-Bin. IMPROVED PREPARATION OF 1-ACETYL 4-(4-HYDROXYPHENYL)PIPERAZINE[J]. , 1988, 0(2) |
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| Authors: | LIN Han-Fen YUE Xiang CHEN Wen-Bin |
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| Affiliation: | Shanghai Institute of Pharmaceutical Industry |
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| Abstract: | An improved preparation of the title compound was achievedfrom diethanolamine and 4-aminoanisole via bromination-cyclization in one pot, followed by demethylation and acetylation in an overall yield of 26.4%. |
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| Keywords: | ketoconazole 1-acetyl-4-(4-hydroxyphenyl)piperazine synthesis |
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