| 食管癌预后相关微小RNAs分子研究进展 |
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| 引用本文： | 周鑫,曹博,洪流. 食管癌预后相关微小RNAs分子研究进展[J]. 转化医学杂志, 2015, 4(6): 360-364 |
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| 作者姓名： | 周鑫 曹博 洪流 |
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| 作者单位： | 第四军医大学员一旅,第四军医大学员一旅,第四军医大西京消化病医院消化一科 |
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| 摘 要： | 食管癌的诊断和手术治疗已较为成熟，但预后相关研究仍不足。许多微小RNAs（microRNAs，miRNAs）分子都与食管癌患者的预后相关。作者就目前食管癌预后相关miRNAs的研究进展作一综述，分析miRNAs分子在临床中的应用，如癌组织中变化的miRNAs表达量用于预测食管癌患者的预后、个别循环miRNAs作为新型生物标志物的潜能，应开展更多的临床试验来推进与预后相关的miRNAs分子的应用。
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| 关 键 词： | 生物标志物；食管癌；微小RNAs；预后；生存状况 |
Prognosis related microRNAs in esophageal cancer |
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| ZHOU Xin,CAO Bo and HONG Liu. Prognosis related microRNAs in esophageal cancer[J]. Translational Medicine Journal, 2015, 4(6): 360-364 |
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| Authors: | ZHOU Xin CAO Bo HONG Liu |
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| Abstract: | Despite improvements in detection, surgical resection and adjuvant therapy, the prognosis of esophageal cancer (EC) patients is dismal. A number of microRNAs (miRNAs) are related with the prognosis of EC. This review summarizes the recent advances in prognosis related miRNAs in EC and further envisages future developments in the potential clinical applications of these miRNAs. Altered miRNAs expression of cancer tissues is useful for predicting the prognosis of EC patients. Individual circulating miRNAs have the potential to be used as novel biomarkers. More clinical trials should be performed to promote the clinical use of prognosis related miRNAs. |
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