利福平联合左氧氟沙星治疗骨科术后耐甲氧西林金黄色葡萄球菌感染的临床分析

目的 探讨利福平联合左氧氟沙星治疗骨科手术后耐甲氧耐西林金黄色葡萄球菌的临床疗效及安全性.方法 70例骨科手术后甲氧西林耐药葡萄球菌感染患者分别予以万古霉素(对照组)和利福平联合左氧氟沙星(观察组)治疗.治疗2周后,对比两组的总有效率、细菌清除率及不良反应,并测定患者治疗前后的相关炎性因子水平.结果 治疗后,观察组总有效率(94.29%)高于对照组(80.00%)、细菌清除率(88.57%)高于对照组(68.57%),差异均有统计学意义(P<0.05);两组均未见严重不良反应.观察组治疗后的炎性因子IL-1β、IL-6 及TNF-α水平显著低于对照组同期(P<0.05).结论 利福平联合左氧氟沙星治疗骨科术后耐甲氧西林金黄色葡萄球菌感染的效果显著、安全性高,可明显降低患者血清炎性因子水平.

Efficacy of rifampicin combined with levofloxacin intreating methicillin-resistant staphylococcus aureusinfection resulting from orthopedic surgery

Objective To investigate the clinical efficacy and safety of rifampicin combined with levofloxacin in treating methicillin-resistant staphylococcus aureus resulting orthopedic surgery.Method 70 patients with methicillin-resistant staphylococcal infection resulting from orthopedic surgery were treated with vancomycin (the control group) and rifampicin combined with levofloxacin (the experimental group).After 2 weeks of treatment, the total effective rate, bacterial clearance rate and adverse reaction were compared between the two groups.The level of related inflammatory factors before and after treatment were measured.Findings The total effective rate in the experimental group (94.29%) was higher than that in the control group (80.00%).The bacterial clearance rate (88.57%) was higher than that of the control group (68.57%).The difference was statistically significant (P<0.05).No serious adverse events were observed in both groups.The levels of IL-1β, IL-6 and TNF-α in the experimental group were significantly lower than those in the control group (P<0.05).Conclusion Rifampicin combined with levofloxacin in the treatment of methicillin-resistant staphylococcus aureus infection resulting from orthopedic surgery is effective and safe, which can significantly reduce the count of serum inflammatory factors in patients.