创伤后应激障碍患者的血清细胞因子相关性

目的:探讨海南地区创伤后应激障碍(PTSD)与血清细胞因子的相关性。方法:选择海南地区创伤后应激障碍患者和健康对照者各57例,应用酶联免疫吸附法(ELISA)检测血清中IL-2、IL-4、IL-6、IL-8含量。结果:创伤后应激障碍组血清中IL-2(t=16.017,P=0.000)、IL-6(t=21.292,P=0.000)、IL-8(t=7.006,P=0.000)含量显著高于对照组。两组人群血清中IL-4含量差异无统计学意义。结论:创伤后应激障碍与血清细胞因子含量的变化息息相关,IL-2、IL-6、IL-8可能在PTSD的发病机理中起着重要作用。

Serum Levels of Cytokines Associated with Posttraumatic Stress Disorder

Objective:To study the correlation of post-traumatic stress disorder and serum levels of cytokines in Hainan area.Methods:The patients with post-traumatic stress disorder and healthy controls each 57 in Hainan area were selected,we used the method of enzyme-linked immunosorbent(ELISA)to test IL-2,IL-4,IL- 6,IL-8 levels.Results:Serum IL-2 (t =16.017,P =0.000),IL-6 (t =21.292,P =0.000),IL-8 (t =7.006,P =0.000)in post-traumatic stress disorder group was significantly higher than that in the control group.There was no statisti-cally significant difference in IL-4 between the two groups.Conclusion:Post-traumatic stress disorder is closely re-lated to the change of the serum levels of cytokines.IL-2,IL-6,IL-8 may play an important role in the pathogen-esis of PTSD.