艾司西酞普兰与文拉法辛治疗躯体形式障碍的对照研究

目的:对比艾司西酞普兰与文拉法辛治疗躯体形式障碍的疗效。方法:选择80例躯体形式障碍患者为研究对象,采用随机数字表法分为艾司西酞普兰组和文拉法辛组各40例,治疗6周后,比较两组的临床疗效及安全性。结果:艾司西酞普兰治疗第6周末的汉密尔顿抑郁量表(HAMD)评分分别低于文拉法辛组,差异有统计学意义(t=-2.325,P0.05);两组间症状自评量表(SCL-90)躯体化因子分比较自始至终无显著性差异。治疗6周后,两组间的疗效和总体有效率无差异。结论:艾司西酞普兰治疗躯体形式障碍的疗效与文拉法辛相似且有效,但较文拉法辛更能改善患者的抑郁症状。

Comparative Study of Escitalopram Oxalate and Venlafaxine Hydrochloride in the Treatment of Somatoform Disorder

Objective:To compare the efficacy of escitalopram and venlafaxin in the treatment of somatoform disor-ders.Methods:A total of 80 cases of patients with somatoform disorder as the research object,were randomly divided into escitalopram group and venlafaxine group,40 cases in each group;After 6 weeks of treatment,the clinical effica-cy and safety were compared between the two groups.Results:Hamilton Depression Scale(HAMD)scores was lower in escitalopram group than the venlafaxine group at the sixth weekend of the treatment(t =-2.325,P <0.05);SCL-90 between the two groups had no significant difference before and after treatment.After 6 weeks of treatment,the curative effect and the overall effective rate between the two groups had no difference(P >0.05).Conclusion:The ef-ficacy of escitalopram in the treatment of somatoform disorders is similar to that of venlafaxine,but escitalopram is more effective than venlafaxine in improving the patient's depressive symptoms.