| 50 例原发性肝癌血清多肿瘤标志物的联合检测研究 |
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| 引用本文： | 阴赪宏,文艳,任江波,董忠,李佳,王宝恩. 50 例原发性肝癌血清多肿瘤标志物的联合检测研究[J]. 肿瘤防治研究, 2005, 32(8): 502-504 |
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| 作者姓名： | 阴赪宏 文艳 任江波 董忠 李佳 王宝恩 |
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| 作者单位： | 100050,首都医科大学附属北京友谊医院 |
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| 摘 要： | 目的 观察原发性肝癌（PHC）患者血清多肿瘤标志物联合检测的阳性检出率。方法 应用多肿瘤标志物蛋白质芯片诊断系统，观察50例PHC、13例其他恶性肿瘤患者、43例炎症性疾病患者以及220例正常对照的血清AFP、CA19—9、CA125、CEA、CA242的阳性表达率。结果 PHC组AFP、CA19—9、CA125、CEA、CA242的阳性检出率分别为86％、42％、38％、24％、18％，该5项肿瘤标志物联合检测，阳性栓出率可达96．00％。结论 联合检测AFP、CA19—9、CA125、CEA、CA242等肿瘤标志物，有利于提高PHC的诊断率。
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| 关 键 词： | 原发性肝癌 肿瘤标志物 生物芯片 诊断 |
| 文章编号： | 1000-8578（2005）08-0502-03 |
| 收稿时间： | 2004-10-08 |
| 修稿时间： | 2004-10-08 |
Combined Different Tumor Markers in Detecting 50 Primary Hepatic Carcinoma Cases |
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| YIN Cheng-hong,WEN Yan,REN Jiang-bo,DONG Zhong,LI Jia,WANG Bao-en. Combined Different Tumor Markers in Detecting 50 Primary Hepatic Carcinoma Cases[J]. Cancer Research on Prevention and Treatment, 2005, 32(8): 502-504 |
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| Authors: | YIN Cheng-hong WEN Yan REN Jiang-bo DONG Zhong LI Jia WANG Bao-en |
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| Affiliation: | Beijing Friend Hospital Affiliated of Capital University of Medical Science , Bei j ing 100050 , China |
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| Abstract: | Objective To increase the detection rate of primary hepatic carcinoma (PHC) by applying dif- ferent tumor markers.Methods Using the different tumor markers Protein Chip Diagnose System to de- termine and analyze the concentration values of5tumor markers in the sera of50PHC patients,13ma- lignant tumor patients,43inflammation patients and230normal persons.Results The positive detection rate of AFP, CA19-9, CA125, CEA and CA242of PHC was86%,42%,38%,24%,18% respective- ly. The total positive detection rate of PHC with combined five tumor markers reached to96.00%.Con- clusion The positive diagnostic accuracy of PHC can be improved by combined the five tumor markers. |
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| Keywords: | Primary hepatic carcinoma Tumor marker Biochips Diagnose |
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