来曲唑治疗PCOS腹腔镜术后不孕的临床分析

目的探讨腹腔镜术后不孕的多囊卵巢综合征患者以来曲唑治疗的临床效果。方法选择腹腔镜术后3个月不孕的多囊卵巢综合征患者60例，随机分为两组，来曲唑组及对照组，对照组以HCG治疗，来曲唑组在HCG治疗基础上加用来曲唑，记录患者HCG日内膜厚度、卵泡成熟时间、成熟卵泡数、周期排卵率、单卵泡排卵率、周期妊娠率、双胎数（例）。结果30例来曲唑组治疗21个周期，15个周期有排卵，5个周期无优势卵泡发育，1个周期有优势卵泡发育未排卵。而对照组，治疗21个周期，14个周期有排卵，5个周期无优势卵泡发育，2个周期有优势卵泡发育未排卵。两组的HCG日内膜厚度、卵泡成熟时间、成熟卵泡数、单卵泡排卵率及双胎数有显著差异（P〈0．05），周期排卵率及周期妊娠率无统计学意义。结论来曲唑能成功诱发术后未孕患者排卵，具有较高的妊娠率。

Clinical Treatment of Research of Letrozole to Infertility after the Laparoscopic Surgery in PCOS

Objective To evaluate the efficacy of letrozole infertility patients with PCOS after the laparoscopic surgery. Methods 60 infertility cases after laparoseopic surgery were randomly divided into two groups, letrozole group and control group, the endometrial thickness, follicle-ripening time,the number of mature follicles ,ovulation rate,a single follicle ovulation rate,pregnancy rate,the number of twins were recorded. Results There was ovulated in 15 cycles,no dominant follicle grew in 5 cycles,and the dominant follicle grew but not ovulated in 1 cycle after 21 cycles treatment in the letrozole group. There was ovulation in 14 cycles,no dominant follicle grew in 5 cycles,and the dominant follicle grew but not ovulated in 2 cycles after 21 cycles treatment in the control group. There were significantly difference of HCG on endometrial thickness, follicle-ripening time, the number of mature follicles, cycle, ovulation rate, a single follicle ovulation rate, cycle, pregnancy rate, the number of twins between the two group （P〈0.05）,ovulation rate and pregnancy rate was not statistically significant. Conclusion There are high ovulation rate and pregnancy rate after treated with letrozole of PCOS patients who can＇ t pregnant after the laparoscopie surgery.