内皮细胞蛋白C受体基因多态性与湖北省地区汉族人群脑梗塞的相关性研究

本研究旨在了解湖北省地区汉族人群内皮细胞蛋白C受体（EPCR）A6936G变异的分布频率，探讨其与脑梗塞的关系。应用PCR-RFLP方法在湖北省地区汉族人群中检测380名脑梗塞患者和380名健康体检者的EPCRA6936G变异。结果表明，脑梗塞患者A／A、A／G和G／G基因型的频率分别为77．1％、22．1％和0．8％，而健康体检者A／A和A／G基因型的频率分别为88．2％和11．8％，未发现G／G基因型。综上所述作出下述结论：湖北省地区汉族人群中存在EPCR A6936G变异，它与脑梗塞患者血栓形成的风险增高有关。

Correlation between Gene Polymorphism of Endothelial Protein C Receptor and Cerebral Infarction in Chinese Han Population of Hubei Province

In order to explore the distribution frequency of endothelial protein C receptor （EPCR） gene A6936G variant and to study the correlation between this mutation and cerebral infarction in Chinese Han population of Hubei province district. The genotype and allele frequencies of EPCR A6936G were identified by polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） in 380 cerebral infarction patients and 380 healthy Chinese Han persons. The results indicated that the frequencies of A/A, A/G and G/G genotypes in cerebral infarction group were 77. 1%, 22.1% and 0.8% respectively. While the frequencies of A/A and A/G genotypes in control group were 88.2% and 11.8%, and without G/G genotype. It is concluded that A6936G polyrnorphism of EPCR can be detected in Chinese Han population of Hubei province district, which may be correlated with the increasing risk of thrombosis in cerebral infarction patients.