A comparative immunohistological study of cerebellar enolases |
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Authors: | Dr M S Ghandour O K Langley A Keller |
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Institution: | (1) Faculté de Médecine de Strasbourg, Institut de Chimie Biologique, 11 rue Humann, F-67000 Strasbourg, France;(2) Groupe de Neurochimie Fonctionnelle, I.N.S.E.R.M. U 171, 8, Avenue Rockefeller, F-69008 Lyon, France |
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Abstract: | Summary A comparative immunohistological study of the neurone-specific ![gamma](/content/v668u821687p90r5/xxlarge947.gif) enolase and ![agr](/content/v668u821687p90r5/xxlarge945.gif) enolase, demonstrates the exclusive neuronal localization of ![gamma](/content/v668u821687p90r5/xxlarge947.gif) enolase and its absence from glial cells. In contrast, ![agr](/content/v668u821687p90r5/xxlarge945.gif) enolase is located in astroglial cells. The validity of ![gamma](/content/v668u821687p90r5/xxlarge947.gif) enolase as a neuronal marker and ![agr](/content/v668u821687p90r5/xxlarge945.gif) enolase as an astrocytic marker, is confirmed both by a double labelling technique, using antibodies to ![agr](/content/v668u821687p90r5/xxlarge945.gif) and to ![gamma](/content/v668u821687p90r5/xxlarge947.gif) revealed with fluorescence or peroxidase in the same tissue sections, and by immunoelectronmicroscopy. |
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Keywords: | Cerebellar enolases Neuronal marker Astrocytic marker Immunohistology |
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