Quantification of soluble serum HLA class I antigens in healthy volunteers and AIDS patients |
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| Authors: | A Ferreira M L Villar J C Alvarez Cerme?o Y Revilla M C García Rodriguez G Fontán P González-Porqué |
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| Affiliation: | Unidad de Immunología, Ciudad Sanitaria La Paz, Madrid, Spain. |
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| Abstract: | A solid-phase enzyme immunoassay (ELISA) has been used to quantify human soluble Class I histocompatibility antigens in serum samples from voluntary blood donors and AIDS patients. Statistical analysis of the results showed significantly raised levels (p less than 0.01) of free HLA Class I in sera from AIDS patients (2.95 +/- 1.80 micrograms/ml) when compared with the blood donors (1.06 +/- 0.6 micrograms/ml). The assay is specific, reproducible and easy to perform. Potential uses of this determination are discussed. |
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