| Fetal Liver Transplantation in the Treatment of β-Thalassemia Major:Report of Two Cases |
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| 作者姓名： | 宋静澄 何杏 周芷芬 张肇和 |
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| 作者单位： | Department of Pediatrics First Military Medical College，Guangzhou，Department of Pediatrics，First Military Medical College，Guangzhou，Department of Pediatrics，First Military Medical College，Guangzhou，Department of Pediatrics，First Military Medical College，Guangzhou |
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| 摘 要： | Two cases of β-thalassemia major treated with fetal liver transplanta-tion(FLT)were reported.A conditioning regimen of total body irradiation pluscyclophosphamide was given,followed by the infusion of suspensions of fetal livercells.The number of nucleated cells(procared from 3 to 4 fetal livers)infused tothe 2 cases was 17.5 and 15.5×10~8/kg respectively.Transient hemopoieticdepression was observed after FLT,and normal hemopoiesis was recoveredaround the 30th day.Karyotypic analysis revealed that the donor typechromosomes was founed in the peripheral blood of both cases from the 20th dayto 123rd day after FLT.Skin biopsy of cass 1 revealed changes of mild GVHD,indicating engrafment of fetal hemopoietic cells and formation of chimeras in thisperiod.Autologous hemopoiesis was reconstituted in both cases two months afterFLT.Blood transfusion was not necessary within the first 5 months after FLT,and in case 1 transfusion was given 3 times only within 21 months after FLT.
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| 关 键 词： | fetus fetal liver transplantation β-thalassemia major |
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