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Bone morphogenic protein-7 serum level decreases significantly in patients with contrast-induced nephropathy |
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| Authors: | Murat Duranay Liviu Segall Nihat Sen Fatma Melik Yilmaz Mustafa Cetin Ahmet Isleyen Mehmet Kanbay Adrian Covic |
| Affiliation: | (1) Department of Internal Medicine, Section of Nephrology, Ankara Training and Research Hospital, Ankara, Turkey;(2) Nephrology Clinic, Dialysis and Renal Transplant Center ‘C.I. PARHON’ University Hospital, ‘Gr. T. Popa’ University of Medicine and Pharmacy, Iasi, Romania;(3) Department of Cardiology, Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey;(4) Department of Biochemistry, Ankara Training and Research Hospital, Ankara, Turkey;(5) Department of Medicine, Section of Nephrology, Fatih University School of Medicine, Alparslan Mahallesi, Umit Sokak, No: 25/14, Melikgazi, Kayseri, Ankara, Turkey; |
| Abstract: | Background and AimPrevious studies have demonstrated that endogenous bone morphogenic protein-7 (BMP-7) level is reduced in acute kidney injury and administration of exogenous BMP-7 has a beneficial effect on kidney function. In spite of preventive management, contrast-induced nephropathy (CIN) is still the third cause of acute deterioration of kidney function in hospitalized patients. With this background in mind, we studied changes in serum BMP-7 in a group of patients with chronic kidney disease and contrast-induced nephropathy. |
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