| MDR1基因C3435T多态性对重症肌无力患者环孢素血药浓度的影响 |
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| 引用本文： | 张亚同,杨莉萍,邵宏,李可欣,孙春华,史录文.MDR1基因C3435T多态性对重症肌无力患者环孢素血药浓度的影响[J].中国临床药理学与治疗学,2005,10(2):133-136. |
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| 作者姓名： | 张亚同 杨莉萍 邵宏 李可欣 孙春华 史录文 |
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| 作者单位： | 1. 北京大学药学院药事管理与临床药学系,北京,100083
2. 北京医院药学部,北京,100730 |
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| 摘 要： | 目的 :研究MDR1基因C3435T多态性与重症肌无力患者环孢素药物动力学的关系。方法 :采用荧光PCR的方法检测 96名重症肌无力 (MG)患者MDR1C3435T基因型 ,其中临床资料较全的 73名 ,对其环孢素用药的血药检测结果与基因型结果分析。结果 :重症肌无力患者MDR1C3435T的分布频率接近 1:1;野生型 3435CC患者的环孢素全血谷浓度高于杂合型和突变型 (P <0 .0 5 ) ,杂合型与突变型之间无明显差异。结论 :药物遗传学研究对环孢素治疗重症肌无力患者的临床合理用药有指导意义。
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| 关 键 词： | MDR1 重症肌无力 环孢素 荧光PCR 药物遗传学 |
| 文章编号： | 1009-2501(2005)02-0133-04 |
| 修稿时间： | 2004年12月16 |
Effects of MDR1 gene C3435T polymorphism on pharmacokinetics of cyclosporine A in myasthenia gravis patients |
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| ZHANG Ya-tong,YANG Li-ping,SHAO Hong,LI Ke-xin,SUN Chun-hua,SHI Lu-wen.Effects of MDR1 gene C3435T polymorphism on pharmacokinetics of cyclosporine A in myasthenia gravis patients[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2005,10(2):133-136. |
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| Authors: | ZHANG Ya-tong YANG Li-ping SHAO Hong LI Ke-xin SUN Chun-hua SHI Lu-wen |
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| Abstract: | AIM: To determine the effects of MDR1 C3435T on the pharmacokinetics of cyclosporine A in myasthenia gravis patients. METHODS: The genotype on MDR1 C3435T in 96 myasthenia gravis patients was detected using real time PCR method and 73 patients of them were studied further to determine the relationship of MDR1 C3435T polymorphism and trough blood concentrations of cyclosporine A. RESULTS: There were no difference between normal people and myasthenia gravis patients in MDR1 C3435T distribution. The average concentrations in patient of MDR1 3435CC was higher than that in patients of MDR1 3435CT and 3435TT. CONCLUSION: The pharmacogenomics is important to rationalize the medication of cyclosporine A. |
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| Keywords: | MDR1 myasthenia gravis cyclosporine A real time PCR pharmacogenomics |
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