白细胞介素1受体拮抗剂等位基因与紫癜性肾炎和IgA肾病的相关联系

目的 为了进一步阐明紫癜性肾炎(HSPN)及IgA肾病(IgAN)二者在发病机理上可能存在的联系。方法 用PCR方法对43例HSPN,97例IgAN患者和98名正常人IL-l受体拮抗剂(IL-lra)基因数目可变的串联重复(VNTR)多态性进行了分析。结果 HSPN患者白细胞介素l受体拮抗剂等位基因(IL IRN 2)的携带率明显高于正常人(P<0.02)和IgAN患者(P<0.05)。在IgAN患者中表现为反复发作性肉眼血尿者其IL IRN 2等位基因的携带率明显高于其它临床类型IgAN患者(P<0.o1),而与HSPN无显著性差异(P>0.05)。结论 HSPN患者IL-lra基因特定的遗传背景在其发病机理中可能起一定作用。IgAN患者中表现为反复发作性肉眼血尿者较其它临床类型IgAN患者与HSPN有更多的相似之处,而ILlRN 2等位基因高携带率可能是二者发病机理的共同点之一。

The association of IL-1 receptor antagonist allele (ILIRN* 2) in Henoch-Schonlein nephritis and IgA nephropathy

Objective To address whether purpura nephritis (HSPN) and IgA nephropathy (IgAN) share a common genetic feature. Methods The gene polymorphism of IL-1 receptor antagonist (IL-lra> has been analyzed among HSPN (n = 43), IgAN(n = 97) and normal control (n = 98) using PCR in the present study. Results The frequency of IL1RN" 2 allele carriage rate was much higher in HSPN than normal subjects (P<0. 02) as well as IgAN (P <0. 05). However, the frequency of IL1RN* 2 carriage rate was significantly higher in IgAN patients with recurrent macroscopic hematuria as compared with other IgAN patients (F<0. 01). Interestingly, there was no difference in the frequency of IL1RN* 2 carriage rate between HSPN and IgAN patients with recurrent macroscopic hematuria. Conclusion IL1RN * 2 allele is a genetic marker which associated with HSPN. The high frequency of IL1RN* 2 carriage may be responsible for the similarities between HSPN and IgAN patients with recurrent macroscopic hematuria.