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| 慢性阻塞性肺疾病肺动脉压和一氧化氮合酶的变化 | |
| 引用本文： | 刘美娟,王蓬伟,林松娟.慢性阻塞性肺疾病肺动脉压和一氧化氮合酶的变化[J].中国现代医学杂志,2008,18(21):3179-3181. |
| 作者姓名： | 刘美娟 王蓬伟 林松娟 |
| 作者单位： | 1. 潍坊医学院临床学院,山东,潍坊,261031 2. 山东省潍坊市妇幼保健院,儿科,山东,潍坊,261010 3. 潍坊医学院附属医院呼吸科,山东,潍坊,261004 |
| 摘 要： | 目的 观察慢性阻塞性肺病大鼠模型肺动脉压力及肺组织一氧化氮含量和一氧化氮合酶表达的变化.方法 Wistar雄性大鼠40只,随机分为COPD组和对照组,应用气道内注入脂多醣和香烟熏吸法制备COPD模型,测定两组大鼠肺动脉平均压力(mPAP)及肺组织匀浆的一氧化氮(NO)含量和诱生型一氧化氮合酶(iNOS)及内皮型一氧化氮合酶(eNOS)的表达情况.结果 COPD组大鼠肺动脉压升高,肺组织的i-NOS表达增强,而NO含量降低、eNOS表达减弱.结论 COPD大鼠肺组织的NO含量降低,eNOS表达减弱,而iNOS表达增强,参与COPD的发生过程,可能是引起肺动脉高压、肺心痛的因素之一. |
| 关 键 词： | 慢性阻塞性肺疾病 一氧化氮 一氧化氮合酶 肺动脉压 |
Variation of pulmonary artery pressure and the nitric oxide synthase in the lung tissue of rats with chronic obstructive pulmonary disease |
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| LIU Mei-juan , WANG Peng-wei , LIN Song-juan.Variation of pulmonary artery pressure and the nitric oxide synthase in the lung tissue of rats with chronic obstructive pulmonary disease[J].China Journal of Modern Medicine,2008,18(21):3179-3181. | |
| Authors: | LIU Mei-juan WANG Peng-wei LIN Song-juan |
| Institution: | LIU Mei-juan1,WANG Peng-wei2,LIN Song-juan3(1.Medical College,Weifang Medical University,Weifang,Sh,ong,261031,P.R.China,2.Department of Pediatrics,Weifang Maternal , Children Health Institute,261010,3.Department of Respiratory,Affiliated Hospital,261004,) |
| Abstract: | Objective To investigate the variation of pulmonary artery pressure and nitric oxide synthase in the lung tissue of rats with chronic obstructive pulmonary disease.MethodsCOPD animal model was established by smoke inhalations and intratracheal instillations of lipopolysaccharide in Wistar rats.The expression of eNOS and iNOS were observed by immunohistochemistry.The concentration of NO in lung tissue homogenate were measured by Nitrate reductase transformation.ResultsThe expression of iNOS and the pulmonary... |
| Keywords: | chronic obstructive pulmonary disease nitric oxide nitric oxide synthase pulmonary artery pressure |
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