Long-term treadmill exercise overcomes ischemia-induced apoptotic neuronal cell death in gerbils |
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Authors: | Sim Young-Je Kim Hong Kim Jee-Youn Yoon Sung-Jin Kim Sung-Soo Chang Hyun-Kyung Lee Taeck-Hyun Lee Hee-Hyuk Shin Min-Chul Shin Mal-Soon Kim Chang-Ju |
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Affiliation: | Department of Exercise Physiology, Graduate School, Korea University, #1 5-Ka Anam-dong, Sungbuk-gu, Seoul 136-701, Republic of Korea. |
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Abstract: | It has been suggested that exercise may ameliorate neurologic impairment by impeding neuronal loss following various brain insults. In the present study, the effect of long-term treadmill exercise on short-term memory and apoptotic neuronal cell death in the hippocampus following transient global ischemia in gerbils was investigated. A step-down inhibitory avoidance task, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay, and immunohistochemistry for caspase-3 were used for this study. Ischemia was induced by occlusion of both the common carotid arteries of gerbils for 5 min. Gerbils in the exercise groups were forced to run on a treadmill for 30 min once a day for 4 consecutive weeks. The present results reveal that treadmill exercise for 4 weeks improved short-term memory by suppressing the ischemia-induced apoptotic neuronal cell death in the hippocampus. Here in this study, we show that long-term treadmill exercise for 4 weeks overcomes the ischemia-induced apoptotic neuronal cell death and thus facilitates the recovery of short-term memory impairment induced by ischemic cerebral injury. |
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Keywords: | Transient global ischemia Apoptotic neuronal cell death Short-term memory Hippocampus Gerbils |
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