| 气传真菌染毒对大鼠外周血单个核细胞白细胞介素-4mRNA表达的影响 |
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| 引用本文： | 阚海东,宋伟民,蒋蓉芳.气传真菌染毒对大鼠外周血单个核细胞白细胞介素-4mRNA表达的影响[J].卫生研究,2001,30(5):269-270. |
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| 作者姓名： | 阚海东 宋伟民 蒋蓉芳 |
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| 作者单位： | 复旦大学公共卫生学院, |
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| 基金项目： | 卫生部科技基金资助项目(No.98-1-167) |
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| 摘 要： | 采用气传真菌孢子混合悬液气管染毒大鼠 ,并以逆转录聚合酶链式反应的方法观察了大鼠外周血单个核细胞 (PBMCs)白细胞介素 4(IL 4)细胞因子mRNA表达情况。结果表明 ,气传真菌孢子气管染毒大鼠可使其外周血单个核细胞高表达IL 4mRNA。实验结果提示IL 4在真菌所致过敏反应中有重要作用。
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| 关 键 词： | 气传真菌 白细胞介素-4 大鼠 |
| 文章编号： | 1000-8020(2001)05-0269-02 |
| 修稿时间： | 2000年10月6日 |
Effect of airborne fungi on interleukin-4 mRNA expression in the peripheral blood mononuclear cells of rats |
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| Kan Haidong,Song Weimin,Jiang Rongfang Public Health School,Fudan University,Shanghai ,China.Effect of airborne fungi on interleukin-4 mRNA expression in the peripheral blood mononuclear cells of rats[J].Journal of Hygiene Research,2001,30(5):269-270. |
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| Authors: | Kan Haidong Song Weimin Jiang Rongfang Public Health School Fudan University Shanghai China |
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| Institution: | Public Health School, Fudan University, Shanghai 200032, China. |
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| Abstract: | The effect of indoor airborne fungi on interleukin 4 (IL 4) mRNA expression in the peripheral blood mononuclear cells (PBMCs) of rats was studied by inoculating via trachea with fungi suspension. A simplified competitive RT PCR method was used to measure the IL 4 mRNA expression in plasma. The results showed that interleukin 4 expression was much higher in the affected groups than that in the control one. It suggested that IL 4 might play an important role in the sensitization progress of fungi. |
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| Keywords: | airborne fungi interleukin 4 rat |
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