Randomized comparison of second trimester pregnancy termination utilizing saline moistened or dry misoprostol |
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Authors: | Bulent Yilmaz Sefa Kelekci Ibrahim Egemen Ertas Murat Ozel Necdet Sut Leyla Mollamahmutoglu Nuri Danisman |
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Affiliation: | (1) Department of Obstetrics and Gynecology, Zekai Tahir Burak Women’s Health Education and Research Hospital, Ankara, Turkey;(2) Department of Obstetrics and Gynecology, Adana Numune Education and Research Hospital, Adana, Turkey;(3) Department of Biostatistics, Trakya University Faculty of Medicine, Edirne, Turkey;(4) Camlitepe Mahallesi, Taskent Sokak, 26/8 Kurtulus, 06600 Ankara, Turkey |
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Abstract: | Objective The aim of this randomized prospective study was to compare efficacy and side effects of saline moistened misoprostol with dry misoprostol, administered 800 μg intravaginally every 6 h up to a maximum of 3 doses in 24 h for second trimester pregnancy termination. Materials and methods A total of 81 women seeking termination of second trimester pregnancy (55 fetal death, 17 fetal structural anomaly, 5 chromosomal abnormality, 4 other reasons) were randomly assigned to one of two treatment groups: (1) intravaginal non-moistened (dry) misoprostol in group A (n = 40) or (2) misoprostol moistened with 3 ml of saline in group B (n = 41). Results All of the patients in either group aborted within 48 h (100% success rate). Delivery was achieved in a median (interquartile range) of 13 (40) h with the group A protocol and 12 (36) h with the group B protocol (P = 0.652). Delivery with first dose, delivery within 12 h and delivery within 24 h were similar (P > 0.05) in group B (34.1, 87.5 and 60%, respectively) and group A (25, 82.9, 46.3, respectively). Both treatment regimens were tolerable and with similar side effects. Conclusion Misoprostol moistened with saline was not more effective than dry misoprostol for second trimester pregnancy termination. |
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Keywords: | Dry Misoprostol Moistened Saline Second trimester pregnancy termination |
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