温热灌注对大鼠肠组织吻合影响的生物力学特性研究

目的：研究腹腔温热灌注疗法对低位直肠切断－吻合术后大鼠直肠愈合的抗拉强度等生物力学性质的影响，同时对鼠肠的本构方程及其粘弹性性质进行深入的分析，为临床提供科学依据。方法：清洁级ＳＤ大鼠３２只，先进行直肠低位切断－吻合术，然后随机分为单纯切断－吻合对照组（Ａ）和腹腔温热灌注组（Ｂ），于术后第５天、　第１５天取材进行生物力学实验。结果：灌注组的抗拉强度、增量弹性模量。粘弹性性能优于对照组，有显著性差异（Ｐ＜０．０５）。结论：采用腹腔温热灌注疗法对直肠癌低位吻合术后直肠组织的生物力学特性，不仅无不良影响，且有助于组织力学性能的改善。

THE BIOMECHANICAL STUDY OF THE EFFECT OF LUKEWARM WATER FILLING ON RATS INTESTINAL ANASTOMOSIS

Objective:To study the therapy of abdominal cavity lukewarm water filling on the effect of biomechanical properties, such as tensile strength of rat rectal healing area after low rectal cutting-anastomosis, and to analyse further the constitution equation and viscoelasticity properties of rat rectum, in order to provide scientific basis for clinical therapy. Methods: There were 32 SD rats of the clean grade. At first performed the low rectal cuttinganastomosis, and then divided into control groupA of sinple cutting-anastomosis without filling and group B of abdominal cavity lukewarm water filling. Biomechanical experiments were done 5 days and 15 days after operation. Results: The tensile strength, elasticity modulus of increasing quantity and viscoelasticity of group B were significantly better than control group A, (P<0.05). Conclusion: By using the therapy of abdominal cavity lukewarm water filling, the biomechanical properties of rectal tissue after low anastomosis of rectal cancer was not only without any notable adverse effect, but also helpful to the improvement of rectal tissue biomechanical properties.