| Peripheral nerve repair by conduits made of human hair keratin：An experimental study |
| |
| 引用本文： | 胡庆柳,朴英杰.Peripheral nerve repair by conduits made of human hair keratin：An experimental study[J].中国人民解放军军医大学学报,2002,17(1):10-13. |
| |
| 作者姓名： | 胡庆柳 朴英杰 |
| |
| 作者单位： | DepartmentofAnatomy,FirstMilitaryMedicalUniversity,Guangzhou510515,China |
| |
| 基金项目： | Supported by National 863 Project of China (No. 102090503) |
| |
| 摘 要： | Objective: To explore the method to repair injured peripheral nerve using conduits made of human hair keratin (HHK). Methods: The tibial nerves of rabbits were transected leaving a gap 10 mm in length between the 2 severed ends, which were either routinely sutured or bridged using HHK nerve conduits. Electro-physiological , anatomical and histological examinations were performed at different time postoperatively. Results: Electrophysiological study showed more obvious improvement in the neural function recovery in rabbits with HHK conduits bridging as compared with that in rabbits with routine suture. In the former group, HHK conduits were gradually degraded and absorbed with large amount of myelinated nerve fibers and Schwann cells regenerated around HHK conduits. In the latter group, however, the nerve tissues around the suture were degenerated and replaced by connective tissues. Conclusion: HHK may induce the regeneration of the nerve fibers and provides an ideal approach to repair nerve damages.
|
| 关 键 词： | 人发角蛋白 外周神经损伤 修复 |
Peripheral nerve repair by conduits made of human hair keratin: An experimental study |
| |
| HU Qing-liu,PIAO Ying-jie.Peripheral nerve repair by conduits made of human hair keratin: An experimental study[J].Journal of Medical Colleges of PLA(China),2002,17(1):10-13. |
| |
| Authors: | HU Qing-liu PIAO Ying-jie |
| |
| Abstract: | Objective: To explore the method to repair injured peripheral nerve using conduits made of human hair keratin (HHK). Methods: The tibial nerves of rabbits were transected leaving a gap 10 mm in length between the 2 severed ends, which were either routinely sutured or bridged using HHK nerve conduits. Electro-physiological , anatomical and histological examinations were performed at different time postoperatively. Results: Electrophysiological study showed more obvious improvement in the neural function recovery in rabbits with HHK conduits bridging as compared with that in rabbits with routine suture. In the former group, HHK conduits were gradually degraded and absorbed with large amount of myelinated nerve fibers and Schwann cells regenerated around HHK conduits. In the latter group, however, the nerve tissues around the suture were degenerated and replaced by connective tissues. Conclusion: HHK may induce the regeneration of the nerve fibers and provides an ideal approach to repair nerve damages. |
| |
| Keywords: | human hair keratin tibial nerve repair |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
