Oxidative and antioxidative status in pregnant women with either gestational or type 1 diabetes |
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Authors: | Peuchant Evelyne Brun Jean-Luc Rigalleau Vincent Dubourg Liliane Thomas Marie-Josée Daniel Jean-Yves Leng Jean-Joël Gin Henri |
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Affiliation: | Biologie de la Différenciation et du Développement, Université Victor Segalen, 33076 Bordeaux cedex, France. evelyne.peuchant@chu-bordeaux.fr |
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Abstract: | OBJECTIVES: To evaluate oxidative and antioxidative status in pregnant diabetic women between 26 and 32 weeks of gestation. DESIGN AND METHODS: Free and total malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPX), and vitamins A and E were determined in plasma and erythrocytes of 54 pregnant women. Among these, 27 were diabetics with either gestational diabetes mellitus (GDM), sub-group I, or previous insulin-dependent diabetes mellitus (type 1 diabetes), sub-group II. The other 27 patients were controls. Fasting plasma glucose and HbA(1c) levels were determined in all women. RESULTS: HbA(1c) levels, plasma-, and erythrocyte-free MDA levels were significantly higher in all diabetic women and in both sub-groups than in controls. Plasma vitamin E and erythrocyte vitamin A levels were significantly lower in all diabetic women than in controls. Moreover, GPX and SOD activities were significantly reduced in all diabetic women, GPX in both sub-groups and SOD only in type 1 diabetes. CONCLUSIONS: The increased oxidative stress we demonstrated in pregnant women with previous type 1 diabetes or with GDM should be monitored by strictly controlling blood glucose during pregnancy with stringent recommendations and perhaps antioxidant supplementation. |
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Keywords: | Oxidative stress Antioxidant Gestational diabetes mellitus Insulin-dependent diabetes mellitus Pregnancy Malondialdehyde Vitamin A Vitamin E Glycosylated hemoglobin |
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