佛波酯对白血病细胞诱导分化的研究进展

12-氧-十四烷酰佛波醇-13-乙酸酯(TPA)是一种从巴豆油中提取的蛋白激酶C(PKC)激活物,具有最高的促癌活性,同时也是最强的诱导分化剂之一.它具有诱导恶性肿瘤细胞分化、促进淋巴细胞转化和淋巴因子分泌的作用,它可诱导HL-60、HEL等多种白血病细胞系以及原代白血病细胞的分化.文章重点阐述TPA对白血病细胞的诱导分化作用及其机制,为白血病的防治提供重要的理论根据.

The study of induction and differentiation of leukemic cell by phorbol ester

12-O-tetradecanoylphorbol-13-acetate (TPA) is an activator of protein kinase C (PKC)extracted from the croton oil, it is one of the most powerful inducers of differentiation as well as a powerful tumor promoter. It is used by the study of induction and differentiation generally, because of it can induce the differentiation of tumor cell and promote the lymphocyte transformation and secrete of lymphokine, meanwhile,it is able to induce many kinds of cell of leukemic cell strain like HL-60, HEL and so on, Some literature reported that TPA had the function of differentiation of primary leukemic cell. The article mainly explains the induction and differentiation of leukemic cell by phorbol ester as well as its mechanisms, which to provide the theory evidence for prevention and cure of leukemia.