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| (1R,2S)-2-氨基-1-苯基-1-丙醇的合成 | |
| 引用本文： | 蔡小华,刘志华,胡薇,杨志学,姚祖凤.(1R,2S)-2-氨基-1-苯基-1-丙醇的合成[J].华西药学杂志,2002,17(2):109-111. |
| 作者姓名： | 蔡小华 刘志华 胡薇 杨志学 姚祖凤 |
| 作者单位： | 1. 怀化医专药学系,湖南,怀化,418000;南昌机电化工研究所,江西,南昌,330047 2. 怀化医专药学系,湖南,怀化,418000 3. 南昌机电化工研究所,江西,南昌,330047 4. 吉首大学化学系,湖南,吉首,416000 |
| 摘 要： | 目的：改进（1R，2S）－2－氨基－1－苯基－1－丙醇的合成工艺。方法：以苯丙酮为起始原料，经中间体肟基苯丙酮和Pt-Pd/C催化加氢反 应合成赤式2－氨基－1－苯基－1－丙酮，再用S－羧甲基－L－半胱氨酸作拆分试剂进行拆分，得到目标产物。结果：收率和光学纯度有较大提高，总收率达55．5％。结论：该工艺具有工业应用价值。 |
| 关 键 词： | 苯丙酮 肟基苯丙酮 （1R 2S）－2－氨基－1－苯基－1－丙醇 合成 |
| 文章编号： | 1006-0103(2002)02-0109-03 |
| 修稿时间： | 2001年9月1日 |
SYNTHETIC OF ERYTHO-2-AMINO-1-PHENYL- 1-PROPANOL |
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| CAI Xiao-hua ,LIU Zhi-hua ,HU Wei ,YANG Zhi-xue ,YAO Zu-feng.SYNTHETIC OF ERYTHO-2-AMINO-1-PHENYL- 1-PROPANOL[J].West China Journal of Pharmaceutical Sciences,2002,17(2):109-111. | |
| Authors: | CAI Xiao-hua LIU Zhi-hua HU Wei YANG Zhi-xue YAO Zu-feng |
| Institution: | CAI Xiao-hua 1,2,LIU Zhi-hua 1,HU Wei 2,YANG Zhi-xue 1,YAO Zu-feng 3 1.Department of Pharmaceutical,Huaihua Medical College,Huaihua 418000,China 2.Chemical Engneering Institute of Nanchang,Nanchang 330047,China 3.Department of Chemistry,Jish |
| Abstract: | OBJECTIVE To improvement synthetic processing of erytho-2-amino-1-phenyl-1-propanol.METHODS It was started from propiophenone ,via the intermediate oximinoacephenone and catalytic hydrogenation.RESULTS Some improvements was made, the cost was low, the processing was simple and the yield was increased. Its total yield was 55.5%. CONCLUSION This processing will have applicable values. |
| Keywords: | Propiophenone Oximinoacephenone Erytho-2-amino-1-phenyl-1-propanol |
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