妊娠高血压综合征患者血清中TNF,MDA及SOD水平的测定及其意义

[目的 ]探讨肿瘤坏死因子 (TNF)、丙二醛 (MDA)浓度及超氧化物歧化酶 (SOD)活性在妊娠高血压综合征发病中的作用及对胎儿生长的影响 .[方法 ]用放射免疫法、硫代巴比妥酸法及黄嘌呤氧化酶法测定 44例妊娠高血压综合征患者血清中TNF ,MDA浓度及SOD活性 .[结果 ]中、重度妊娠高血压综合征组与正常对照组比较 ,各指标间均有显著性差异 ,妊娠高血压综合征组的TNF及SOD与MDA的比值呈显著负相关 ;合并胎儿宫内发育迟缓者血清中TNF及MDA浓度均明显高于未合并胎儿宫内发育迟缓者 ,而SOD活性明显低于未合并胎儿宫内发育迟缓者 .[结论 ]血清中TNF ,MDA浓度及SOD活性的变化在妊娠高血压综合征的发病及胎儿宫内发育迟缓的发生中起一定的作用

Study on changes of TNF,MDA and SOD in the pregnancy induced hypertension

OBJECTIVE?To investigate the effects of the TNF, MDA and SOD for the pregnancy induced by hypertension (PIH) and fetal grow th.?METHODS?It was measured by the radioimmunity method, thi obarbituric acid method and xamthoine pxidase method that the changes of TNF, conc entration of MDA and activity of SOD in 44 cases of the PIH as group of the PIH. ?RESULTS?There were significant differences of all indexes bet ween the groups of moderate, severe PIH and normal pregnant. In the PIH group, t here was a significant negative correlation between the ratio of TNF and SOD /MDA . The serum concentrations of TNF and MDA in the IUGR group were obviously h ighe r than that in non IUGR group, the activity of SOD in the IUGR group as obvi ousl y lower than that in non IUGR group.?CONCLUSION?The level of TNF, concentration of MDA and activity of SOD play an important role in the p athogenesis of PIH and IUGR.