| 植物药及果蔬对药物代谢酶P450活性的影响 |
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| 引用本文： | 彭文兴,李焕德,周宏灏.植物药及果蔬对药物代谢酶P450活性的影响[J].中国临床药理学杂志,2003,19(2):145-148. |
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| 作者姓名： | 彭文兴 李焕德 周宏灏 |
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| 作者单位： | 1. 中南大学,湘雅二医院,临床药学研究室,湖南,长沙,410011
2. 中南大学,临床药理研究所,湖南长沙,410038 |
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| 摘 要： | 中草药及其他植物药在我国及东南亚国家应用广泛，在欧美也逐渐受到重视，一些中草药及植物药可能诱导或抑制肝脏细胞色素P450(CYP)药物代谢酶，从而引起自身及其他合用药物代谢的改变，因此可能导致药物不良反应和药物相互作用。
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| 关 键 词： | 植物药 果蔬 药物代谢酶 P450活性 细胞色素P450 |
Effect of Plant Drug, Vegetable and Fruit on The Activity of The Cytochrome P450 |
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| PENG Wen-xing LI Huan-de ZHOU Hong-hao.Effect of Plant Drug, Vegetable and Fruit on The Activity of The Cytochrome P450[J].The Chinese Journal of Clinical Pharmacology,2003,19(2):145-148. |
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| Authors: | PENG Wen-xing LI Huan-de ZHOU Hong-hao |
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| Abstract: | Plant drug (including Chinese herbal medicine) are used widely in China and other southeast Asian countries. Some these drugs can inhibit or induce liver cytochrome P450 activity. Thereby influence drug metabolism and maybe cause drug adverse action and toxicity. This article reviews the effect of Chinese herbal medicine and other plant drugs including food on cytochrome P450 reported in recent literature. |
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| Keywords: | Chinese herbal medicine plant drug drug metabolizing enzymes cytoxhrome P450 |
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