| 我国分离人H5N1禽流感病毒血凝素基因特性的研究 |
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| 引用本文： | 舒跃龙,蓝雨,温乐英,赵新生,张烨,董婕,段淑敏,聂凯,张晓光,王大燕,姚丽红,郭元吉. 我国分离人H5N1禽流感病毒血凝素基因特性的研究[J]. 中华实验和临床病毒学杂志, 2006, 20(2): 8-10 |
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| 作者姓名： | 舒跃龙 蓝雨 温乐英 赵新生 张烨 董婕 段淑敏 聂凯 张晓光 王大燕 姚丽红 郭元吉 |
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| 作者单位： | 100052,北京,中国疾病预防控制中心病毒病所国家流感中心,传染病预防控制国家重点实验室 |
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| 基金项目： | 国家自然科学基金重大项目（30599433）. |
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| 摘 要： | 目的 分析我国分离的人高致病性禽流感H5N1病毒的抗原性以及基因特性.方法 对所分离的H5N1病毒的血凝素基因和神经氨酸酶基因进行序列测定.结果 对血凝素基因的序列测定结果表明从我国分离的H5N1病毒具有较高的同源性,但是与越南、泰国等国家分离的H5N1病毒明显不同.序列测定的结果同时表明无论是受体特异性还是连接肽都是禽源的.结论 目前我国分离的H5N1病毒属于同一个组,与泰国、越南分离毒株不同,并且发现病毒的特性仍然是禽源的,没有发现从禽到人的重组或者重配。
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| 关 键 词： | H5N1禽流感病毒 基因特性 |
| 收稿时间： | 2006-03-10 |
| 修稿时间： | 2006-03-10 |
Analysis of human H5N1 virus hemagglutinin gene isolated from the mainland of China |
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| SHU Yue-long,LAN Yu,WEN Le-ying,ZHAO Xin-sheng,ZHANG Ye,DONG Jie,DUAN Shu-min,NIE Kai,ZHANG Xiao-guang,WANG Da-yan,YAO Li-hong,GUO Yuan-ji. Analysis of human H5N1 virus hemagglutinin gene isolated from the mainland of China[J]. Chinese journal of experimental and clinical virology, 2006, 20(2): 8-10 |
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| Authors: | SHU Yue-long LAN Yu WEN Le-ying ZHAO Xin-sheng ZHANG Ye DONG Jie DUAN Shu-min NIE Kai ZHANG Xiao-guang WANG Da-yan YAO Li-hong GUO Yuan-ji |
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| Affiliation: | Chinese Influenza Center, Institute for Viral Disease Control and Prevention, State Key Laboratory for Infectious Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, China |
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| Abstract: | Objective To analyze the genetic and antigenic characteristics of human H5N1 virus isolated from the mainland of China. Methods The hemagglutinin (HA) gene of human H5N1 virus were sequenced and analyzed. Results The results of HA gene sequencing showed that all the virus isolates belong to the same group because of the high similarity, but they were different with the virus isolated from Thailand and Vietnam. The sequence data also showed that the receptor specificity and the connecting peptide between HA1 and HA2 are still avian influenza origin. Conclusion The virus isolates from mainland of China until now belong to the same group and are different from the virus isolated from Thailand and Vietnam, and there is no evidence showing the human-avian influenza reassortant and recombination. |
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| Keywords: | H5N1 avian influenza Genetic characterization |
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