| 瘦素与非酒精性脂肪性肝纤维化研究进展 |
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| 引用本文： | 王亚东,赵彩彦. 瘦素与非酒精性脂肪性肝纤维化研究进展[J]. 国际消化病杂志, 2007, 27(5): 367-369 |
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| 作者姓名： | 王亚东 赵彩彦 |
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| 作者单位： | 河北医科大学第三临床医院感染科,050051 |
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| 摘 要： | 瘦素是肥胖基因编码的代谢性激素,主要在白色脂肪组织特异表达,结合受体后介导细胞信号转导途径,通过调节肝脏间质细胞功能、调控转化生长因子β(TGF-β)、肿瘤坏死因子α(TNF-α)等细胞因子的分泌以及诱导胶原生成与降解失衡等,参与非酒精性脂肪性肝纤维化的发生发展。
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| 关 键 词： | 非酒精性脂肪性肝纤维化 瘦素 转化生长因子 |
| 修稿时间： | 2005-09-24 |
Research progress of the leptin and nonalcoholic fatty liver fibrosis |
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| WANG Ya-dong,ZHAO Cai-yan. Research progress of the leptin and nonalcoholic fatty liver fibrosis[J]. International Journal of Digestive Disease, 2007, 27(5): 367-369 |
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| Authors: | WANG Ya-dong ZHAO Cai-yan |
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| Abstract: | Leptin is a kind of metabolic hormone encoded by obese gene in blanc adipose tissue.After binding with its receptors,leptin could produce biological effect to promote the development of nonalcoholic fatty liver fibrosis through signal transduction pathway,such as regulating interstitial cells function,enhancing expression of cytokines,unbalancing the production and degradation of collagen and so on. |
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| Keywords: | Nonalcoholic fatty liver fibrosis Leptin Transforming growth factor |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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