肝卵圆细胞调控机制研究进展

肝卵圆细胞是一类存在于成年肝脏、具有自我更新和多向分化潜能的肝干细胞。当肝脏发生严重损伤且肝细胞再生障碍时,卵圆细胞被激活并大量增殖,参与肝脏损伤的修复与重建。肝卵圆细胞增殖分化是多因素作用的结果。现就肝卵圆细胞的定位、来源及调控机制的研究进展作一概述。

Study of regulatory mechanism in hepatic oval cell

Hepatic oval cells(HOC) are the progenitor cells existing in the adult liver,with the capacity to self-renew as well as the ability to generate differentiated cells.Oval cells are activated to proliferate and regenerate liver tissue when the liver damage is extensive and chronic,or if proliferation of hepatocytes is inhibited.Many factors are involved in regulating the proliferation and differentiation of HOC.This review focuses on the location,origin and regulatory mechanism of HOC.