Seroepidemiology and genotypes of hepatitis C virus in Thailand |
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Authors: | Sunanchaikarn Srunthron Theamboonlers Apiradee Chongsrisawat Voranush Yoocharoen Pornsak Tharmaphornpilas Piyanit Warinsathien Porpit Sinlaparatsamee Supakarn Paupunwatana Siriraj Chaiear Kasemporn Khwanjaipanich Sawan Poovorawan Yong |
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Affiliation: | Center of Excellence in Viral Hepatitis Research, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. |
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Abstract: | HCV can be classified into 6 major genotypes based on the phylogenetic analysis of the genomic sequences. The 3 major genotypes found in Thailand are 3, 1 and 6, respectively. In 2004, an epidemiological survey was carried out to evaluate the seroprevalence of HCV infections among populations aged 2-60 years in four provinces of Thailand, representing the North, Northeast, Center and South of the country, respectively. One hundred and twenty five out of 5,825 serum samples (2.15%) were positive for anti-HCV by ELISA. Fifty eight out of 100 anti-HCV positive samples (58.0%) were positive by RT-PCR of the 5'UTR. The core region of 45 representative samples was sequenced allowing classification into genotype variants 1a (6.7%), 1b (26.7%), 2a (2.2%), 2c (2.2%), 3a (51.1%), 3b (2.2%) and 6 (8.9%). This information might be crucial for public health surveillance and prevention of HCV infection. |
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