Influence of fluid resuscitation on renal microvascular PO2 in a normotensive rat model of endotoxemia

Introduction  

Septic renal failure is often seen in the intensive care unit but its pathogenesis is only partly understood. This study, performed in a normotensive rat model of endotoxemia, tests the hypotheses that endotoxemia impairs renal microvascular PO₂ (μPO₂) and oxygen consumption (VO_2,ren), that endotoxemia is associated with a diminished kidney function, that fluid resuscitation can restore μPO₂, VO_2,ren and kidney function, and that colloids are more effective than crystalloids.