活血祛淤解毒方治疗寻常型银屑病血淤证的临床研究

目的 评价北京地区名老中医经验方活血祛淤解毒方治疗寻常型银屑病血淤证的临床疗效及安全性,以及对患者血液流变学及皮损浸润程度的影响.方法 将42例寻常型银屑病血淤证患者随机分为治疗组和对照组,治疗组口服活血祛淤解毒方,对照组口服接诊医师自拟方.观察两组的临床疗效及PASI评分,并同时检测两组治疗前后血液流变学及皮损浸润程度的改变.结果 治疗组、对照组总有效率分别为73.68%,82.61%,无统计学差异(P>0.05).两组治疗后PASI评分均降低(P<0.01)、血浆粘度均降低(P<0.05),治疗组皮损真皮厚度明显降低(P<0.01),对照组皮损表皮、真皮厚度均降低(P<0.05).结论 活血祛淤解毒方治疗寻常型银屑病血淤证疗效满意,与医师自拟方疗效相当,值得临床推广应用.其作用机制可能在于降低血液粘度、改善微循环、减轻皮损浸润程度.

Clinical Trail of Huoxue-quyu-jiedu Formula in Treating Blood Stasis Syndrome of Psoriasis Vulgaris

Objective To evaluate the clinical effects and safety of Huoxue - quyu - jiedu formula created by a few famous herbalist doctors in Beijing on blood stasis syndrome of psoriasis vulgaris,and to observe its influence on hemorheology and soakage degrees of skin lesions . Methods 42 patients were selected and randomly divided into 2 groups: therapeutic group and control group. Patients in the therapeutic group took Huoxue - quyu - jiedu formula and those in the control group had the recipe prescribed by doctors themselves for 8 weeks. Therapeutic effect and PASI scores were recorded and the influence on hemorheology and soakage degrees of skin lesions were observed before and after treatment. Results The effective rates were 73.68% and 82.61% in the therapeutic group and in the controll group respectively. There was no statistical difference in therapeutic effects between the two groups(P >0.05 ). PASI scores decreased in both groups and showed significant difference statistically before and after treatment( P<0.01). Plasma viscosity decreased in both groups and showed statistical difference before and after treat-ment(P< 0.05). The dermis thickness decreased significantly in therapeutic group (P<0.01). The epidermis and dermis thickness both decreased in the control group (P<0.05). Conclusion Huoxue - quyu - jiedu formula had a satisfying effect on treating blood stasis syndrome of psoriasis vulgaris, similar to the recipes prescribed by doctors themselves. It is worth to clinical application and extension. Its mechanism probably lies in reducing the plasma viscosity, improving microcirculation and reducing the soakage degree of skin rash.