宫颈癌危险因素的病例对照研究

目的 探讨宫颈癌发生的危险因素。方法 采用以医院为基础的病例对照研究方法，对125例经病理学确诊的宫颈癌新发病人和相同数量的子宫肌瘤患者进行包括基本信息、月经婚孕、性行为及卫生习惯等方面的问卷调查以及HPV16感染状况和GSTM1、GSTT1基因型别检测，对资料进行X^2检验，t检验，分级分析及多因素logistic回归分析。结果 GSTM1基因型、HPV16感染状况、绝经情况、首次性交年龄、首次怀孕年龄、孕次、职业作为主要因素进入回归模型。结论 GSTM1基因纯合缺失、HPV16感染是宫颈癌发生的主要危险因素。首次性交年龄早、首次怀孕年龄早、多孕可增加宫颈癌发生的危险，绝经和从事脑力劳动具有保护性意义。

Case-control study on risk factors of cervical cancer

Objective To investigate the risk factors of cervical cancer. Methods A hospital-based case-control study was conducted. One hundred and twenty-five cases with cervical cancer and 125 controls with hysteromyoma by pathological diagnosed from Shanxi Tumor Hospital were involved in this study.All cases and controls were interviewed using a questionnaire,including basic information,sexual behavior and heath habits,menstrual,marriage and pregnancy history,etc. The status of HPV16 infectien,GSTM1 and GSTT1 genotypes were detected. All data were analyzed by SPSS11. 0 using X^2-test, t-test and multiple non-conditional logistic regression analysis. Results GSTM1 genotype, infection with HPV16, age at first sexual intercourse, age at first pregnancy, times of pregnancy and occupation were involved in multiple logistic regression medal. Conclusion GSTM1 null genotype and infection with HPV16 play important roles in the development of cervical cancer. Young age at first sextual intercourse or pregnancy, more frequencies of pregnancy are risk factors for cervical cancer, but postmenopause and engaged in brainwork are protective factors for cervical cancer.