| 实验性大鼠糖尿病高脂血症模型制作方法的改进 |
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| 引用本文： | 李卫红,孔晓平,李青钊.实验性大鼠糖尿病高脂血症模型制作方法的改进[J].华北煤炭医学院学报,2007,9(3):301-303. |
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| 作者姓名： | 李卫红 孔晓平 李青钊 |
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| 作者单位： | 1. 华北煤炭医学院实验动物中心,河北唐山,063000
2. 河北省第一劳教所 |
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| 摘 要： | ①目的探讨实验性大鼠2型糖尿病高脂血症动物模型方法的建立。②方法大鼠分4次腹腔注射四氧嘧碇，同时喂饲高脂饮食，于第1次给药后的48小时、1周、2周，6周分别测定空腹血糖及体重以及甘油三酯与胆固醇含量的变化。③结果成功诱导实验性大鼠2型糖尿病高脂血症动物模型。④结论连续多次给予四氧嘧碇，同时喂饲高脂饮食，能成功诱导2型糖尿病高脂血症动物模型，且成功率高，动物死亡率低。
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| 关 键 词： | 糖尿病 动物模型 四氧嘧啶 高脂血症 |
| 文章编号： | 1008-6633（2007）03-0301-03 |
| 收稿时间： | 2006-10-11 |
| 修稿时间： | 2006年10月11 |
Improved method for the model of diabetic hyperlipidemia in experiment rats |
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| LI Weihong,KONG Xiaoping,LI Qingzhao.Improved method for the model of diabetic hyperlipidemia in experiment rats[J].Journal of North China Coal Medical College,2007,9(3):301-303. |
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| Authors: | LI Weihong KONG Xiaoping LI Qingzhao |
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| Institution: | LI Weihong, KONG Xiaoping, LI Qingzhao ( North China Coal Medical College, Tangshan 063000, China) |
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| Abstract: | Objective To explore the method of establishing model of type Ⅱ diabetic hyperlipidemia in experiment rats. Methods Rats were injected with alloxoan four times and fed with the high - fat diets. The fasting blood sugar, body weight, triglyceride and cholesterol were measured for 48 h, 1 week ,2 week and 6 week after the first injection. Results The model of diabetic hyperlipidemia in rats was induced successfully. Conclusions The animal model of type Ⅱ diabetic hyperlipidemia was induced by injecting alloxoan and feeding with the high - fat diets many times continuously. |
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| Keywords: | Diabetic Animal model Alloxoan Hyperlipoid |
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