不同作用机理的三种药物对小鼠抗缺氧存活的研究

目的探究酒石酸美托洛尔、盐酸氟桂利嗪、盐酸特拉唑嗪对小鼠抗缺氧能力的影响。方法将小鼠随机分为对照组和给药组,通过建立的常压密闭缺氧模型和亚硝酸钠血液性缺氧模型实验,及小鼠模拟10 000米高原急性减压缺氧耐力实验,研究3种药物对小鼠抗缺氧能力的影响。结果酒石酸美托洛尔、盐酸氟桂利嗪、盐酸特拉唑嗪的低、中、高剂量组与对照组相比,均能显著延长小鼠在常压密闭缺氧环境中的存活时间（P〈0.05）,其中3种药物的低剂量均能显著延长小鼠亚硝酸钠血液性缺氧（P〈0.05）和10 000米高原急性减压缺氧环境的存活时间（P〈0.05）。结论 3种药物均有不同程度的提高小鼠抗缺氧能力的作用,而给予低剂量美托洛尔（0.26 mg.kg-1）、氟桂利嗪（0.325 mg.kg-1）、特拉唑嗪（0.13mg.kg-1）的药物相比于正常剂量的效果更优,可用于临床指导合理用药。

Three Different Mechanisms of Drugs on Mouse Anti-hypoxia Survival Inquiry

Objective To study the effects of Three different mechanisms of chemical drugs-Metoprolol hydrochloride,flunarizine hydrochloride,hydrochloric terazosin hydrochloride,on anti-hypoxia ability of mice.Methods The rats were randomly divided into control group and treatment group.The effect and anti-hypoxia ability of three drugs of rats were investigated by the established atmospheric pressure airtight hypoxia model,sodium nitrite hematologic hypoxia model,and simulated 10 000 m altitude acute decompression hypoxia endurance model.Results The low,medium and high dose groups of metoprolol tartrate,flunarizine hydrochloride,terazosin hydrochloride,compared with the control group,can significantly prolong the survival time of mice on atmospheric pressure airtight hypoxia model（P0.05）,in which the low doses of these three drugs could significantly prolong the sodium nitrite hematologic hypoxia model（P 0.05） and mice simulated 10 000 m altitude acute decompression hypoxia endurance model（P0.05） survival time.Conclusion The anti-hypoxia ability of rats were improved using the different dose groups of three drugs.And the better anti-hypoxia ability of rats were obtaind that the low dose of metoprolol（0.26 mg · kg-1）,flunarizine（0.325 mg · kg-1） and terazosin（0.13 mg · kg-1） compared to the normal dose.It can be used to guide clinical rational drug use.