| 基质细胞衍生因子-1及其受体CXCR4在成体干细胞迁移中的作用 |
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| 引用本文： | 龚启梅,蒋宏伟,凌均棨.基质细胞衍生因子-1及其受体CXCR4在成体干细胞迁移中的作用[J].国际口腔医学杂志,2008,35(4). |
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| 作者姓名： | 龚启梅 蒋宏伟 凌均棨 |
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| 作者单位： | 中山大学光华口腔医学院·附属口腔医院牙体牙髓病科,广东,广州,510055;中山大学光华口腔医学院·附属口腔医院牙体牙髓病科,广东,广州,510055;中山大学光华口腔医学院·附属口腔医院牙体牙髓病科,广东,广州,510055 |
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| 摘 要： | 基质细胞衍生因子-1是一种重要的造血与非造血系干细胞形态发生因子和趋化因子。基质细胞衍生因子-1与其受体CXCR4结合,所介导的成体干细胞迁移归巢在多种组织器官损伤后的再生修复中发挥重要作用。基质细胞衍生因子-1及其受体CXCR4组成的功能轴在成体干细胞尤其是骨髓源干细胞迁移方面的研究进展,为研究牙髓干细胞迁移提供了新的方向。
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| 关 键 词： | 基质细胞衍生因子-1 CXCR4 迁移归巢 干细胞 |
The role of stromal cell derived factor-1 and its receptor CXCR4 in the migration of adult stem cells |
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| GONG Qi-mei,JIANG Hong-wei,LING Jun-qi.The role of stromal cell derived factor-1 and its receptor CXCR4 in the migration of adult stem cells[J].Journal of International Stomatology,2008,35(4). |
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| Authors: | GONG Qi-mei JIANG Hong-wei LING Jun-qi |
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| Abstract: | Stromal cell derived factor-1(SDF-1) is an important regulator of morphogenesis and chemiotaxis thatrelated to both hematopoietic and non-hematopoietic stem cells. It has been recently shown that SDF-1 binding toits receptor(CXCR4) is important in mediating the migration/homing of adult stem cells, therefore plays a pivotalrole in regeneration and reparation after tissue/organ injury. Research advances of SDF-1/CXCR4 axis in the migration of adult stem cells may provide a new way to study dental pulp stem cells(DPSC) migration, especially in the bone marrow-derived stem cells. |
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| Keywords: | stromal cell derived factor-1 CXCR4 migration homing stem cell |
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