Genetic control of instrumental conditioning by striatopallidal neuron-specific S1P receptor Gpr6 |
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| Authors: | Lobo Mary Kay Cui Yijun Ostlund Sean B Balleine Bernard W Yang X William |
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| Affiliation: | Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience & Human Behavior, University of California at Los Angeles, 695 Charles Young Drive South, Los Angeles, California 90095, USA. |
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| Abstract: | Instrumental conditioning allows animals to learn about the consequences of their own actions, but the underpinning molecular mechanisms remain elusive. Here we show that the sphingosine-1-phosphate (S1P) receptor Gpr6 is selectively expressed in the striatopallidal neurons in the striatum. Gpr6-deficient mice showed reduced striatal cyclic AMP production in vitro and selective alterations in instrumental conditioning in vivo. Thus, Gpr6 is the first striatopallidal neuron-specific genetic regulator of instrumental conditioning in a mammal. |
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