| 脑白质疏松症患者载脂蛋白E基因多态性与血脂水平的关系 |
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| 引用本文： | 陈志斌,涂蓉,钱士匀,蔡美华,姚红霞,苏庆杰.脑白质疏松症患者载脂蛋白E基因多态性与血脂水平的关系[J].海南医学院学报,2005,11(1):6-8. |
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| 作者姓名： | 陈志斌 涂蓉 钱士匀 蔡美华 姚红霞 苏庆杰 |
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| 作者单位： | 海南医学院附属医院神经内科,海口,570102 |
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| 基金项目： | 海南省卫生厅资助课题(琼卫课题9809) |
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| 摘 要： | 目的:探讨脑白质疏松症患者载脂蛋白E基因多态性与血脂水平的关系。方法:采用聚合酶链反应———限制片段长度多态性对50例脑白质疏松症患者和108例正常对照者载脂蛋白E基因型进行分析并进行血脂水平测定。结果:脑白质疏松症患者ApoE2等位基因频率为0.15,明显高于对照组的0.074(P<0.05);含ApoE2等位基因患者的甘油三酯、低密度脂蛋白;载脂蛋白B的含量均高于ApoE3等位基因患者。结论:载脂蛋白E2等位基因可能是脑白质疏松症的一种遗传易感因子,ApoE基因多态性可能通过影响血脂水平而影响脑白质疏松症的发生。
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| 关 键 词： | 白质软化病 脑室周围 载脂蛋白E 等位基因 |
| 文章编号： | 1007-1237(2005)01-0006-03 |
| 修稿时间： | 2004年12月20 |
THE RELATIONSHIP BETWEEN APOLIPOPROTEIN E GENE POLYMORPHISMS AND LEVEL OF SERUM LIPIDS IN PATIENTS WITH LEUKOARAIOSIS |
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| CHEN Zhi-bin,TU Rong,QIAN Shi-yun,et al..THE RELATIONSHIP BETWEEN APOLIPOPROTEIN E GENE POLYMORPHISMS AND LEVEL OF SERUM LIPIDS IN PATIENTS WITH LEUKOARAIOSIS[J].Journal of Hainan Medical College,2005,11(1):6-8. |
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| Authors: | CHEN Zhi-bin TU Rong QIAN Shi-yun |
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| Abstract: | Objective: To study the relationship between polymorphisms of apolipoprotein E gene and serum lipids in leukoaraiosis patients. Methods:The polymerase chain reaction (PCR) and restriction fragment length polymorphism)RFLP) technique were used to detect Apo E genotype in 50 leukoaraiosis patients and 108 control group and serum lipids levels were detected also. Result:The frequency of Apo E2 allele in the leukoaraiosis group was significantly higher than that in the control group)P < 0.05(. The levels of TG?LDL-c and Apo B in leukoaraiosis patient`s the Apo E2 group wassignificantly higher that in the Apo E3 group. Conclusion:Allele Apo E2 seemed to be a genetic suscep-tible factor for leukoaraiosis. Apo E gene polymorphism maybe related to leukoaraiosis by affecting serumlipids levels. |
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| Keywords: | Malacopathia of white matter Around ventricle Apolipoprotein E Allelic gene |
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