| 薯蓣皂苷元对小鼠下腔静脉结扎血栓形成及相关因子的影响 |
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| 引用本文： | 田友清,丁平,寇俊萍,余伯阳.薯蓣皂苷元对小鼠下腔静脉结扎血栓形成及相关因子的影响[J].现代中药研究与实践,2007,21(1):32-34. |
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| 作者姓名： | 田友清 丁平 寇俊萍 余伯阳 |
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| 作者单位： | 1. 江苏联合职业技术学院连云港中医药分院,江苏,连云港,222006
2. 中国药科大学中药复方研究室,江苏,南京,210038 |
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| 摘 要： | 目的研究薯蓣皂苷元对静脉血栓形成的影响,并初步探讨其抗血栓作用的机理。方法通过小鼠下腔静脉结扎,测定形成血栓的重量及血清和血管壁内NO与MPO水平的变化。结果薯蓣皂苷元对小鼠下腔静脉结扎血栓形成具有抑制作用,能使血清中NO升高,而血管壁内的NO降低,MPO则升高。结论薯蓣皂苷元通过影响血液和血管壁内NO与MPO水平而发挥抗血栓形成作用。
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| 关 键 词： | 薯蓣皂苷元 抗血栓形成 NO MPO |
| 文章编号： | 1004-2199（2007）01-0032-03 |
| 收稿时间： | 2006-02-01 |
| 修稿时间： | 2006年2月1日 |
Effect of Diosgenin on Stasis-Induced Venous Thrombosis in Mice |
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| TIAN You-qing,Ding Ping,KOU Jun-ping,YU Bo-yang.Effect of Diosgenin on Stasis-Induced Venous Thrombosis in Mice[J].Research and Practice on Chinese Medicines,2007,21(1):32-34. |
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| Authors: | TIAN You-qing Ding Ping KOU Jun-ping YU Bo-yang |
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| Abstract: | Objective To study effect of diosgenin on stasisinduced venous thrombosis and its mechanism.Methods The weight of thrombus was measured,the change of NO and MPO in serum and venous vessel wall were determined through the model of inferior vena cava ligation.Results Diosgenin could inhibit the thrombosis significantly,promote production of NO in serum and MPO in venous vessel wall,decrease production of NO in venous vessel wall.Conclusion Diosgenin showed that it was a significant anti-thrombus through regulating production of NO and MPO in serum and venous vessel wall. |
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| Keywords: | Diosgenin anti-thrombus NO MPO |
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