Rh factor, family history and risk of breast cancer: A case-control study in Uruguay |
| |
Authors: | Alvaro L. Ronco,Mario Stoll,Eduardo De Sté fani,Juan E. Maisonneuve,Beatriz A. Mendoza,Hugo Deneo-Pellegrini |
| |
Affiliation: | a Departamento de Epidemiología y Métodos Científicos, Facultad de Medicina, IUCLAEH, Maldonado, Uruguay b Unidad de Mastología, Instituto de Radiología y Centro de Lucha Contra el Cáncer, Centro Hospitalario Pereira Rossell, Bvar.Artigas 1550, Montevideo 11200, Uruguay c Área Genética Molecular, Comisión Honoraria para la Salud Cardiovascular, Bvar.Artigas 2358, Montevideo 11200, Uruguay d Cátedra de Endocrinología y Metabolismo, Hospital de Clínicas, Facultad de Medicina, Universidad de la Republica, Av.Italia s/n y Las Heras, Montevideo 11200, Uruguay e Grupo de Epidemiología, Departamento de Anatomía Patológica, Hospital de Clínicas, Facultad de Medicina, Universidad de la República, Av.Italia s/n y Las Heras, Montevideo 11200, Uruguay |
| |
Abstract: | Objective: To explore possible relationships among blood factors, family history of breast cancer (BC) and the risk of the disease, a case-control study was carried out in Montevideo, Uruguay. Methods: Eight hundred and one patients were interviewed, including 252 certified cases of BC and 549 frequency-matched controls. Blood groups (ABO, Rh) were obtained from medical records. Multivariate analyses were performed, adjusting for age, selected menstrual and reproductive factors, and family history of BC as well as of other cancers. Results: We found that the absence of Rh factor (Rh−) was positively associated with the risk of BC (adjusted Odds Ratio [OR] = 1.49, 95% Confidence Interval [95% CI] 1.05-2.11). Stratified analyses by family history of BC showed a strong association for Rh− with a positive history of first degree relatives (OR = 3.17, 95% CI 1.06-9.47). Also stratified analyses by family history of other cancers showed a positive association for Rh− with a positive history of first degree relatives (OR = 2.08, 95% CI 1.05-4.11). Conclusion: Regarding the implications of an inherited factor like Rh and its associations with the family history of BC, it might increase the probability to generate high-risk individuals if further studies confirm the present preliminary findings. |
| |
Keywords: | Breast cancer Blood factors Epidemiology Family history |
本文献已被 ScienceDirect 等数据库收录! |
|