口腔鳞状细胞癌组织癌性锚蛋白重复序列蛋白的表达及意义

目的探讨癌性锚蛋白重复序列(gann ankyrin repeats,gankyrin)蛋白在口腔鳞状细胞癌中的表达及临床意义。方法采用免疫组化方法检测55例口腔鳞状细胞癌组织及癌旁黏膜组织中gankyrin蛋白表达水平,观察口腔鳞状细胞癌不同临床病理特征下gankyrin蛋白的表达差异,分析其可能的临床价值。结果口腔鳞状细胞癌组织中gankyrin蛋白表达远高于癌旁黏膜组织(P=0.000)。高、中低分化鳞癌组间gankyrin蛋白表达差异有统计学意义(P=0.006);不同性别、年龄及有无淋巴结转移鳞癌组gankyrin蛋白表达差异无统计学意义。结论 Gankyrin蛋白高表达于口腔鳞状细胞癌,且与肿瘤分化程度相关。

Expression of ankyrin repeats in oral squamous cell carcinoma and its clinical significance

ObjectiveTo investigate the expression of ankyrin repeats in oral squamous cell carcinoma(OSCC) and its clinical significance. MethodsThe expression of gankyrin protein was detected by immunohistochemical method in 55 OSCC specimens and the corresponding para-cancer non-tumor tissues; the differential expression of gankyrin protein was analyzed in OSCC specimens of different pathological characteristics; we also analyzed the possible clinical value of the differential expression. ResultsExpression of gankyrin in the OSCC tissues was significantly stronger than that in the corresponding para-cancer non-tumor tissues (P=0.000). Gankyrin protein expression was significantly different between OSCC tissues of high,low and moderate differentiation (P=0.006). We also found that the expression of gankyrin was not associated with the sex, age, or lymphatic status of OSCC patients. ConclusionGankyrin protein is over-expressed in OSCC tissues,which might be related to the differentiation degree of OSCC.