Musashi1 regulates breast tumor cell proliferation and is a prognostic indicator of poor survival |
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| Authors: | Xiao-Yang Wang Luiz OF Penalva Hongyan Yuan R Ilona Linnoila Jiachun Lu Hideyuki Okano Robert I Glazer |
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| Affiliation: | (1) Department of Oncology, Georgetown University, and Lombardi Comprehensive Cancer Center, Washington, DC 20007, USA;(2) Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA;(3) Department of Cell and Structural Biology, University of Texas Health Science Center at San Antonio, TX, USA;(4) Department of Epidemiology, State Key Lab of Respiratory Disease, Guangzhou Medical College, Guangzhou, Guangdong, China;(5) Department of Physiology, Keio University School of Medicine, Tokyo, Japan |
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| Abstract: | Background Musashi1 (Msi1) is a conserved RNA-binding protein that regulates the Notch and Wnt pathways, and serves as a stem cell marker in the breast and other tissues. It is unknown how Msi1 relates to other breast cancer markers, whether it denotes tumor initiating cells (TICs), and how it affects gene expression and tumor cell survival in breast cancer cells. |
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