| 补肾活血方对拟血管性痴呆小鼠脑NMDA受体和一氧化氮合酶的影响 |
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| 引用本文： | 张孟仁,郭赛珊. 补肾活血方对拟血管性痴呆小鼠脑NMDA受体和一氧化氮合酶的影响[J]. 中医杂志, 2000, 41(12): 745-747 |
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| 作者姓名： | 张孟仁 郭赛珊 |
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| 作者单位： | 中国医学科学院中国协和医科大学北京协和医院 |
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| 摘 要： | 探讨补肾活血方防治拟血管痴呆（Ｖａｓｃｕｌａｒ ｄｅｍｅｎｔｉａ，ＶＤ）小鼠的药理机制，用双颈总动脉闭塞－缺血－再灌术造成拟ＶＤ小鼠模型。观察补肾活血方对拟ＶＤ小鼠学习记忆能力、脑海马Ｎ－甲基－Ｄ－门冬氨酸（ＮＭＤＡ）受体及一氧化氮合酶（ＮＯＳ）活性的影响。结果证实，补肾活血方能明显缩短拟ＶＤ小鼠在Ｍｏｒｒｉｓ水迷宫中找到站台所需时间，改善学习记忆能力，抑制ＶＤ小鼠脑海马ＮＭＤＡ受体及ＮＯＳ活性的升高，对抗兴奋毒性和ＮＯ对神经元的损伤，从而保护神经元免受损伤。
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| 关 键 词： | 血管性痴呆 中医药治疗 补肾活血方 NMDA受体 |
| 修稿时间： | 1999-04-02 |
Effects of Bu Shen Huo Xue Fang on NMDA Receptor and Nitric Oxide Synthase of Brain in Mice of Vascular Dementia |
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| Zhang Mengren,Guo Saishan Beijing Union Hospital,China Union Medical University,Chinese Academy of Medical Sciences,Beijing. Effects of Bu Shen Huo Xue Fang on NMDA Receptor and Nitric Oxide Synthase of Brain in Mice of Vascular Dementia[J]. Journal of Traditional Chinese Medicine, 2000, 41(12): 745-747 |
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| Authors: | Zhang Mengren Guo Saishan Beijing Union Hospital China Union Medical University Chinese Academy of Medical Sciences Beijing |
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| Affiliation: | Zhang Mengren,Guo Saishan Beijing Union Hospital,China Union Medical University,Chinese Academy of Medical Sciences,Beijing 100730 |
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| Abstract: | The present paper approached to mechanisms of Bu Shen Huo Xue Fang preventing and treating vascular dementia (VD) in mice. The effects of Bu Shen Huo Xue Fang on study and memory ability, and NMDA receptor and activity of nitric oxide synthase (NOS) in hippocampus were observed in VD mice. Results prove that Bu Shen Huo Xue Fang can markedly shorten the time of the mice of VD looking out the plantform in Morris'water maze, improve study and memory ability, inhibit NMDA receptor in hippocampus and increase NOS activity, antagonize excitatory toxicity and neuron injury induced by NO, so as to protect neurons from damage. |
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| Keywords: | dimentia vascular/TCM therapy |
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