Slow recovery of the maximal rate of rise (dot V_{max} ) of the action potential in sheep cardiac Purkinje fibers期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Slow recovery of the maximal rate of rise (dot V_{max} ) of the action potential in sheep cardiac Purkinje fibers

Authors:	T. Saikawa E. Carmeliet

Affiliation:	(1) Laboratory of Physiology, University of Leuven, Gasthuisberg, B-3000 Leuven, Belgium;(2) Present address: Department of Internal Medicine, Oita Medical School, 879-56 Oita, Japan

Abstract:	Measurements of the maximal rate of rise ( $dot V_{max }$ ) of the action potential in cardiac Purkinje fibers were made at different intervals following an action potential or a long-duration depolarization. Recovery of $dot V_{max }$ is fast after a short depolarization but is composed of a fast phase and a very slow phase (time constant order of 1 s) after a long-duration depolarization. The existence of a slow phase in the recovery explains the shift of the ( $dot V_{max }$ - E_m) relationship to negative potentials in fibers with reduced resting potential.

Keywords:	maximal rate of rise potential dependence recovery Purkinje fiber
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