毛细支气管炎患儿T细胞亚群变化及治疗观察

目的：探讨毛细支气管炎患儿免疫功能状态及双黄连的干预作用。方法：用间接免疫荧光法测定110例毛细支气管炎患儿T细胞亚群CD3^ ,CD4^ ,CD8^ ,CD4^ /CD8^ ,并将其随机分成两组：双黄连组（58例在常规用药基础上加用双黄连）及常规组（52例，除不用双黄连外，其余相同）。结果：110例毛支患儿中CD8^ ,CD4^ 均下降，CD8^ 上升，CD4^ /CD8^ 下降，用双黄连治疗后，患儿临床症状、体征及免疫功能恢复均优于常规治疗组（P＜0．01）。结论：毛支患儿存在免疫功能异常及免疫调节功能紊乱，注射双黄连为治疗小儿毛细支气管炎的有效药物。

T Lymphocyte Subpoputation Changes and Curative Observation in Children Bronchiolitis

Objective To study immune function of children bronchiolitis and to evaluate the clinical effect of Shuanghuanglian powder (SHLP).Methods The authors determined the numbers of lymphocyte Subpoputation CD 3?CD 4?CD 8?CD 4/CD 8 with bronchiolitis patients by indirect immunofluorescent assay.110 patients were divided randomly into two groups.58 cases were treated by conventional therapy with SHLP and the other 52 cases treated with conventional therapy alone were taken as control group.Results The level of CD 3?CD 4,cells and the ratio of CD 4/CD 8 were decreased while CD 8 increased .After treatment with SHLP, the recovery of symptoms signs and immune function in patients were better than that of controls.These changes were significant different (P<0.01).Conclusions There were disturbance of immune regulatory function with children bronchiolitis and SHLP is a effective drug in treating children bronchiolitis.