Myelin basic protein-specific T lymphocytes proliferation and programmed cell death in demyelinating diseases |
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Authors: | Saresella Marina Marventano Ivana Guerini Franca Rosa Zanzottera Milena Delbue Serena Marchioni Enrico Maserati Renato Longhi Renato Ferrante Pasquale Clerici Mario |
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Institution: | Laboratory of Molecular Medicine and Biotechnology, Don C. Gnocchi Foundation ONLUS, IRCCS S. Maria Nascente, Via Capecelatro 66, 20148, Milan, Italy. |
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Abstract: | A dynamic equilibrium between proliferation and programmed cell death (PCD) of auto-reactive T lymphocytes plays a pivotal role in the prevention of autoimmune diseases. We analyzed T lymphocytes myelin basic protein (MBP)-specific PCD and proliferation in demyelinating diseases. Results showed that MBP-specific PCD was significantly decreased in CD4+ and CD8+ T lymphocytes of progressive multifocal leukoencephalopathy (PML), not determined leukoencephalopathy (NDLE), and acute MS (AMS) patients compared to patients with stable MS (SMS) and healthy controls. MBP-specific proliferation/PCD rates were high in CD4+ T lymphocytes of PML, NDLE, and AMS patients, and in CD8+ T cells of PML and AMS individuals alone. Alterations of the balance between MBP-specific proliferation and PCD are present in demyelinating diseases and could play a major role in the pathogenesis of these diseases. |
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Keywords: | PCD Myelin basic protein Demyelinating diseases Apoptosis Multiple sclerosis |
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