| 抑制创面收缩药物的实验研究 |
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| 引用本文： | 刘文阁,李素娟,杨佩瑛. 抑制创面收缩药物的实验研究[J]. 中国美容医学, 1998, 0(2) |
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| 作者姓名： | 刘文阁 李素娟 杨佩瑛 |
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| 作者单位： | 国防科工委，国防科工委，北京整形外科医院 黄寺美容外科医院(北京 100011)，黄寺美容外科医院(北京 100011) |
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| 摘 要： | 为研究罂粟碱抑制创面收缩的效果与机理,用浸有不同浓度的罂粟碱溶液的纱布覆盖豚鼠背部2cm 直径的创面,并以生理盐水对照,观察创面面积变化,测定肉芽组织羟脯氨酸含量。发现罂粟碱能显著地抑制创面收缩,其抑制程度与药物浓度呈正相关,以0.3%,罂粟碱液为较有治疗效果的浓度机理在作用于成肌纤维细胞所致。
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| 关 键 词： | 创面收缩 罂粟碱 |
THE EXPERIMENTAL RESEARCH OF INHIBITING WOND CONTRACTION BY PAPAVERINE |
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| Liu Wenge Li Sujuon Yang peiying Beijing Huangsi Aesthetic Surgery Hospital. THE EXPERIMENTAL RESEARCH OF INHIBITING WOND CONTRACTION BY PAPAVERINE[J]. Chinese Journal of Aesthetic Medicine, 1998, 0(2) |
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| Authors: | Liu Wenge Li Sujuon Yang peiying Beijing Huangsi Aesthetic Surgery Hospital |
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| Affiliation: | Beijing 100011 |
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| Abstract: | In this Study.full-thickness dorsal skin wounds were made in guinea pigs.These animals were divided into three groups:A,B,C,group A wound was dressed with saline daily and served as control,wound of group B and C was dressed with 0.01% and 0.3% papaverine.We found papaerine could inhibit wound contraction bignificantly and had a dose-response effect.The results indicate that wound contraeeion inhibition by papaverine is mediated by its effects on the myofibrablasts. |
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| Keywords: | Wound cautraction Papaverine |
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