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| 广东汉族鼻咽癌与DPB1-3'调控区多态性相关研究 | |
| 引用本文： | 王培,邹华,丁琳,陈秋坚,郑亿庆,吴玉萍,徐安龙,刘宜敏,孔月萍. 广东汉族鼻咽癌与DPB1-3'调控区多态性相关研究[J]. 临床耳鼻咽喉头颈外科杂志, 2010, 24(6) |
| 作者姓名： | 王培 邹华 丁琳 陈秋坚 郑亿庆 吴玉萍 徐安龙 刘宜敏 孔月萍 |
| 作者单位： | 1. 广东药学院附属第一医院耳鼻咽喉头颈外科,广州,510100 2. 中山大学附属第二医院耳鼻咽喉头颈外科 3. 中山大学生命科学院 |
| 基金项目： | 广东省科技计划项目(No:2006B36001007) |
| 摘 要： | 目的:探讨广东地区汉族人鼻咽癌和DPB1-3'调控区的相关性,寻找易感基因类型。方法:对104例广东藉的汉族NPC患者和105例广东藉对照者进行HLA-DPB1基因调控区分型及比较。结果:鼻咽癌组DPB1位点3'调控区BB基因型、B单倍型等位基因分布频率、明显高于对照组。结论:DPB1位点3'调控区BB基因型、B单倍型等位基因可能与广东地区汉族人群鼻咽癌的发生有关。 |
| 关 键 词： | 鼻咽肿瘤 HLA-DPB1基因 3'调控区 多态性 |
Association of regulatory region of HLA-DPB1 with Nasopharyngeal carcinoma in Southern Chinese Hans |
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| WANG Pei,ZOU Hua,DING Lin,CHEN Qiujian,ZHENG Yiqing,WU Yuping,XU Anlong,LIU Yimin,KONG Yueping. Association of regulatory region of HLA-DPB1 with Nasopharyngeal carcinoma in Southern Chinese Hans[J]. Journal of clinical otorhinolaryngology, head, and neck surgery, 2010, 24(6) | |
| Authors: | WANG Pei ZOU Hua DING Lin CHEN Qiujian ZHENG Yiqing WU Yuping XU Anlong LIU Yimin KONG Yueping |
| Affiliation: | 1Department of Otorhinolaryngology-Head and Neck Surgery/a>;Guangzhou/a>;510120/a>;China/a>;2Department of Otorhinolaryngology-Head and Neck Surgery/a>;the Second Affiliated Hospital/a>;Sun Yat-sen University/a>;3College of Life Science/a>;Sun Yat-sen University |
| Abstract: | Objective:To clarify the association between regulatory region of HLA-DPB1 (3'UTR) with Nasopharyngeal carcinoma in Guangdong Province Hans.Method:The allelictypes of HLA-DPB1-3'UTR were detected by sequence specific primer (SSP) in 104 patients with NPC and 105 control individuals from Guangdong Province Hans.Result:The frequencies of allelictypes B/B,haplotype B were higher in patients with NPC than those of the control individuals.Conclusion:Positive association may exist between certain HLA-DPB1 alleles... |
| Keywords: | nasopharyngeal neoplasms HLA-DPB1 regulatory region polymorphism |
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