| Establishment and characterization of two cell lines derived from human transitional cell carcinoma. |
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| 作者姓名： | 畅继武 隋志芳 马腾骧 马昆 张欣 王建军 董克权 姚庆祥 |
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| 作者单位： | Tianjin Institute of Urologic Surgery，Second Affiliated Hospital，Tianjin Medical University，Tianjin 300211，Tianjin Institute of Urologic Surgery，Second Affiliated Hospital，Tianjin Medical University，Tianjin 300211，Tianjin Institute of Urologic Surgery，Second Affiliated Hospital，Tianjin Medical University，Tianjin 300211，Kunming Animal Institute，Chinese Academy of Science，Kunming，Tianjin Institute of Urologic Surgery，Second Affiliated Hospital，Tianjin Medical University，Tianjin 300211，Tianjin Institute of Urologic Surgery，Second Affiliated Hospital，Tianjin Medical University，Tianjin 300211，Department of Urologic Surgery，Second Affiliated Hospital，Tianjin Medical University，Tianjin，Department of Urologic Surgery，Second Affiliated Hospital，Tianjin Medical University，Tianjin |
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| 摘 要： | Two continuous cell lines derived from the neoplastic urothelium had been maintained in culture for more than two years. The first cell line derived from the urothelium of a fusion papillocarcinoma on the left lateral wall of the bladder was designated as TBC-1 and grown in vitro for more than 150 generations. The second cell line derived from the urothelium of a papillocarcinoma in the left renal pelvis was designated as TPC-1 and grown in vitro for more than 100 generations. Characterization studies made on both cell lines showed that the cells had a rapid doubling time, exhibited mul-tilayering and produced tumors in sc of BALB / c. Tumor nodules that produced sc of BALB / c kept similar cellular and pathological features to those of the primary biopsy specimens under light and electron microscopes. TPC-1 cell line exhibited a three-dimensional structure of transitional epithelium on the nylon-mesh disk which was coated with a layer of rat tail collagen. Both TBC-1 and TPC-1 cell lines formed colonies
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