| 口腔鳞癌患者唾液cyfra 21-1含量与癌组织CK19表达的相关性研究 |
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| 引用本文： | 钟来平,张志愿,胡宇华,王丽珍,李江,陈万涛,张陈平.口腔鳞癌患者唾液cyfra 21-1含量与癌组织CK19表达的相关性研究[J].中国口腔颌面外科杂志,2010,8(2):160-164. |
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| 作者姓名： | 钟来平 张志愿 胡宇华 王丽珍 李江 陈万涛 张陈平 |
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| 作者单位： | 1. 上海交通大学医学院附属第九人民医院·口腔医学院,口腔颌面外科,上海市口腔医学重点实验室,上海,200011
2. 上海交通大学医学院附属第九人民医院·口腔医学院,口腔病理科,上海市口腔医学重点实验室,上海,200011 |
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| 摘 要： | 目的：检测口腔鳞癌患者唾液中cyfra21-1含量、组织中CK19蛋白质表达和基因转录水平,探讨其相互关系。方法：对30例口腔鳞癌患者和30例正常人的唾液采用ELISA法检测cyfra21-1含量,其中6例口腔鳞癌患者的癌组织和癌旁组织分别采用免疫组织化学和实时定量RT-PCR法检测CK19蛋白质表达强度和CK19mRNA水平,采用SPSS10.0软件包进行统计学分析。结果：口腔鳞癌患者唾液cyfra21-1含量为（85.95±78.00）μg/L,显著高于对照组的（42.27±40.84）μg/L;口腔鳞癌癌组织CK19蛋白质表达强度和CK19mRNA水平显著高于癌旁组织。CK19mRNA水平与CK19蛋白质表达强度呈显著正相关,癌组织CK19蛋白质与唾液cyfra21-1含量也显著相关。结论：口腔鳞癌患者唾液cyfra21-1含量和组织CK19蛋白表达及基因转录水平显著升高,组织CK19表达升高,对唾液cyfra21-1含量的上升起着重要作用。
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| 关 键 词： | 口腔鳞癌 唾液 Cyfra 21-1 CK19 |
Correlation between cyfra 21-1 concentration in saliva and CK19 expression in tissues from oral squamous cell carcinoma patients |
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| ZHONG Lai-ping,ZHANG Zhi-yuan,HU Yu-hua,WANG Li-zhen,LI Jiang,CHEN Wan-tao,ZHANG Chen-ping.Correlation between cyfra 21-1 concentration in saliva and CK19 expression in tissues from oral squamous cell carcinoma patients[J].China Journal of Oral and Maxillofacial Surgery,2010,8(2):160-164. |
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| Authors: | ZHONG Lai-ping ZHANG Zhi-yuan HU Yu-hua WANG Li-zhen LI Jiang CHEN Wan-tao ZHANG Chen-ping |
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| Institution: | ZHONG Lai-ping1,ZHANG Zhi-yuan1,HU Yu-hua2,WANG Li-zhen2,LI Jiang2,CHEN Wan-tao1,ZHANG Chen-ping1.(1.Department of Oral , Maxillofacial Surgery,2.Department of Oral Pathology,Ninth People\'s Hospital,College of Stomatology,Shanghai Jiao Tong University School of Medicine,Shanghai Key Laboratory of Stomatology.Shanghai 200011,China) |
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| Abstract: | PURPOSE:To investigate the cyfra 21-1 concentration in saliva,CK19 protein expression and CK19mRNA level in tissues from oral squamous cell carcinoma patients as well as their relationships.METHODS:The cyfra 21-1 concentration in saliva from 30 oral squamous cell carcinoma patients and 30 healthy adults were detected by ELISA,the CK19 protein expression in cancerous and para -cancerous tissues from 6 oral squamous cell carcinoma patients were detected by immunohistochemistry,and the CK19mRNA level was detec... |
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| Keywords: | Oral squamous cell carcinoma Saliva Cyfra 21-1 CK19 |
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